| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 봄 (05/12 ~ 05/14, 부산 벡스코(BEXCO)) |
| 권호 |
25권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Enhanced malignant tumor chemo-immunotherapy using nanomicelle generating microneedles containing paclitaxel and TLR7/8 agonist |
| 초록 |
Dissolving microneedles(MNs) offer an effective way for advanced drug delivery systems. Efficient drug delivery of low dose chemical therapy agent paclitaxel and immune-modulators adjuvants-resiquimod was synergized to demonstrate anti-cancer effect and activation of antigen-presenting cells. Paclitaxel treatment was speculated to cause malignant tumor cell death which should lead to production of tumor-specific antigens. Resiquimod was used as an adjuvant and was anticipated to induce maturation and activation of immune cells for eliciting anticancer immune response. In this study, two hydrophobic therapeutic drugs being were dispersed with the help of an amphiphilic triblock copolymer. The capability of concurrent delivery of two agents-loaded NMCs was researched by watching the induced secretion of pro-inflammatory cytokines which are considered for anti-cancer activity and the expression of maturation markers (CD40,CD80) which elicit a much stronger immune stimulation effect. |
| 저자 |
황위보, 임수연, 김다훤, LYUSIYAN, 김병덕, 박채은, 정지훈
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| 소속 |
성균관대 |
| 키워드 |
생체재료; 마이크로니들; 면역
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| E-Mail |
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