| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
고분자 가공/복합재료 |
| 제목 |
Poly (ε-caprolactone)-grafted-poly(vinyl alcohol) nanoparticles: Hydrophobicand hydrophilic drugs carrier nanoparticles |
| 초록 |
Nanoparticles(NPs) possessing the capability of carrying hydrophobic and hydrophilic drugs had been produced. Poly ε-caprolactone grafted polyvinyl alcohol PCL-g-PVA has been prepared and shaped in NPs form to be adequate for carrying the drug.The formed PCL was attached as branches with PVA backbone.FT-IR has confirmed formation of PCL-g-PVA.The thermal alteration in coplymer was checked by TGA.The copolymer was able to self-aggregate into NPs by dialysis.The size,morphology and charges associated with the obtained NPs were analyzed by DLS,TEM and ELS,respectively.In-vitro drug release experiments were conducted;the loaded NPs reveal continuous and sustained release drugs,up to 20 and 15 days for paclitaxel and doxorubicin,respectively. In a case of using pure drugs only,both drugs completely released within 1 to 2 h. The proposed strategies recommended the use these NPs in future drug delivery systems. |
| 저자 |
세익페힘아바멘1, 김학용2, 나지르3, 무자파4, 다만5, 길명섭6
|
| 소속 |
1전북대, 2Department of Textile Engineering, 3Chonbuk National Univ., 4Chonju 561-756, 5Republic of Korea, 6헬스케어사업단 |
| 키워드 |
Nanoparticle; hydrophobic; hydrophilic; paclitaxel and doxorubicin
|
| E-Mail |
|
