| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Antimicrobial Peptide Mimetic Functional Polyethers |
| 초록 |
Antimicrobial peptide (AMP) is one of the key components of the immune system found in various plants, insect, and animals. The main mechanism is known to attach and destroy the bacterial cells membrane or to penetrate the cell membrane and inhibit cell metabolism. To date, there have been active investigations to imitate these peptides and build new artificial systems that complement their disadvantages such as proteolysis, low in vivo efficacy, and hemolytic behavior. In this study, we design and synthesize a novel AMP mimetic polyethers by using three functional epoxide monomers mimicking natural amino acid. All monomers are successfully synthesized and copolymerized by anionic ring-opening polymerization (AROP). Their biological activities toward diverse bacteria and the hemolytic concentration toward human red blood cell are determined. We anticipate the potentials of designer epoxide monomers for the synthesis of functional polyethers toward peptidomimetics. |
| 저자 |
김민성1, 문원식1, 조가영1, 권지수1, Robert James Mitchell1, 김병수2
|
| 소속 |
1울산과학기술원, 2연세대 |
| 키워드 |
antimicrobial polymer; polymer synthesis
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| E-Mail |
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