| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 가을 (10/26 ~ 10/28, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
20권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Spatio-temporal coating for dual functionalized vascular stent |
| 초록 |
Drug-eluting stent (DES) implantation with balloon angioplasty is a widely used treatment for coronary artery diseases. However, DES still causes thrombosis and/or in-stent restenosis as long-term outcomes. For effective prevention of these problems, we fabricated a dual functionalized stent using spatio-temporal coating, which has two different surfaces, as a novel type of DES. Hyaluronic acid conjugated with dopamine (HA-DA) was applied to a bare cobalt-chromium stent prior to abluminal coating of sirolimus (SRL)-in-polymer. The SRL-coated on the abluminal surface of the HA-DA modified stent prevented the crack formation after ballooning. HA-DA coating displayed suitable blood- and cyto-compatibility even under the existence of SRL. In in vivo study, the neointimal area and inflammation score of the dual functionalized stent with HA-DA and SRL were significantly reduced than those of BMS. It is expected that this novel type of DES can be effectively applied for vascular stenosis. |
| 저자 |
정다원1, 김성민1, 박광숙1, 고원건2, 정윤기1, 한동근1
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| 소속 |
1한국과학기술(연), 2연세대 |
| 키워드 |
drug-eluting stent; coating; HA-DA; SRL
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| E-Mail |
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