| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 봄 (04/12 ~ 04/13, 대전컨벤션센터) |
| 권호 |
37권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Improved Transdermal Permeation Behavior of 5-FUusing Non-ionic Surface Activator and Microneedle |
| 초록 |
5-Fluorouracil (5-FU) has been widely used to treat cancer as types of i.v. and oral adminstration. 5-FU is an antimetabolic of the pyrimidine derivatives that is used in chemotherapy for the treatment of several types of cancer. 5-FU have poor oral absorption and short biological half-time. It has low bioavailability of 20 % due to the hepatic first pass effect. Microneedle introduced for find a solution of problems. Microneedle device with roll was manufactured for transdermal delivery of various drugs. 5-FU was mixed in non-ionic surfactant such as tween 20 and tween 80. Camscope was used to analysis the permeation magnitude of treated skin by microneedle and trypan blue stanining. The 5-FU solution with surfactant was measured by ELS-8000 for stability of solution. The skin permeation rate of 5-FU solution was determined by HPLC. The results indicate that skin permeation rate of 5-FU was increased with the treatment types, treatment times and the treatment by microneedle. |
| 저자 |
박 국 빈, 전대연, 이정근, 이유정, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Transdermal; 5-FU; Microneedle; Tween 20; Tween 80; HPLC
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| E-Mail |
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