| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Characteristics and Controlled Dissolution of Aceclofenac Solid Dispersion |
| 초록 |
We prepared nanoparticles containing insoluble aceclofenac by the method of solid dispersions using spray dryer to improve solubility of aceclofenac. We used PVP-K30 as a water soluble carrier for the solid dispersion and poloxamer as a surfactant. Characterization of aceclofenac solid dispersion was performed by scanning electron microscope (SEM), differential scanning calorimetry (DSC), x-ray diffraction (XRD) and fourier-transform infrared spectroscopy (FT-IR). The results of SEM, DSC and XRD demonstrated that aceclofenac is amorphous in solid dispersion. The formation of salt by hydrogen bond between aceclofenac and PVP K-30 was confirmed by FT-IR. The dissolution rate measured in intestinal juice (pH 1.2) showed the method of solid dispersion improved aceclofenac solubility compared with a conventional drug (Airtal®). In conclusion, the method of solid dispersion using spray dryer would improve solubility of aceclofenac in oral administration. |
| 저자 |
장지은, 박국빈, 김영래, 고현아, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Aceclofenac; PVP K-30; Solid dispersion; SEM; DSC; XRD; Spray-drying
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| E-Mail |
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