| 초록 |
In this study, we demonstrated the potential of calcium carbonate (CaCO3) mineralized hybrid nanoparticles for photodynamic therapy. Poly(ethylene glycol)–poly(L-aspartic acid) (PEG-PAsp) can act as a nanotemplate and participated in the formation of the CaCO3 core because of the anionic carboxylates of PAsp. Moreover, the hydrophilic photosensitizer (PS), chlorin e6 (Ce6), can be trapped in CaCO3 core of particles. The nontoxic CaCO3 mineral core allowed the facilitated release of entrapped Ce6 within the acidic intracellular compartments (pH 5.0) such as endosomes and lysosomes. Therefore, this nanoparticle showed the potential not only for minimizing Ce6 loss in blood but also for selective release of Ce6 within cells after tumor targeting. CaCO3 mineralized hybrid nanoparticle seems very promising as a ‘on demand’ nanocarrier system for effective photodynamic therapy. We anticipate the potential advantage for future in vivo and clinical application. |
