| 학회 |
한국공업화학회 |
| 학술대회 |
2005년 가을 (10/28 ~ 10/29, 건국대학교) |
| 권호 |
9권 2호 |
| 발표분야 |
고분자 |
| 제목 |
Water-Soluble Biodegradable Copolymer as Surfactant for Emulsification-Diffusion method : size control of nanoparticles and influence of PEG surface density |
| 초록 |
Stealth nanoparticles were investigated to avoid rapid uptake of drug carriers by cell of the mononuclear phargocyte system (MPS) and reticuloendothelial system (RES). Poly(ethyleneglycol) (PEG) is attached onto stealth nanoparticle surface to avoid recognition by cell of the MPS and physical adsorption. Emulsification-Diffusion method (E-D method) was used to prepare stealth nanoparticles. Monomethoxy poly(ethyleneglycol)-poly(D,L-Lactide) (mPEG-PLA di-block copolymer) and PEG-PLA-PEG tri-block copolymerwas used as surfactant for E-D method. We determined PEG surface density and size. Variables for preparing nanoparticle were surfactant concentration and PLA molecular weight of copolymers. |
| 저자 |
김용우, 한승훈, 박용해, 이종은, 김중현
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| 소속 |
연세대 |
| 키워드 |
biodegradation polymer |
| E-Mail |
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