| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Release of anti-restenosis drugs from polyethylene glycol-co-poly(DL-lactic-co-glycolic acid) nanoparticles. |
| 초록 |
Rapamycin-loaded nanoparticles based on polyethylene glycol(PEG) and poly(DL-lactic-co-glycolic acid)(PLGA) block copolymers (PEG-PLGA) were prepared by dialysis method. The Rapamycin- loaded nanoparticles of the PEG-PLGA copolymer had a particles size of 50-200nm according to drug content and degree of substitution of PEG. The morphology of Rapamycin loaded nanopaticles observed by transmission electron microscopy had spherical shapes with particle size of ＜50nm. Anti-restenosis drug loaded nanoparticles showed high drug loading efficiency over 80 % (w/w). |
| 저자 |
김동곤1, 김은진1, 신일균1, 김한기1, 박종채1, 나재운2, 김상호1
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| 소속 |
1(주)엠아이텍, 2순천대 |
| 키워드 |
Anti-restenosis drug; Rapamycin; PEG-PLGA; nanopaticle; stent
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| E-Mail |
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