| 학회 |
한국공업화학회 |
| 학술대회 |
2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
26권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Hyaluronic acid-modified liposomal nanoplatform for NIR-responsive chemo-photothermal treatment of rheumatoid arthritis |
| 초록 |
The combination of photothermal therapy (PTT) and chemotherapy regarded an effective treatment for diseases such as cancer and inflammation. Herein, we developed a nanoplatform named HMM-Lipo, a NIR-responsive hyaluronic acid (HA)-modified liposome containing methotrexate (MTX) and melanin. Due to HA modification, HMM-Lipo targeted specifically activated CD44 receptor in rheumatoid arthritis (RA). HMM-Lipo was spherical with an average diameter of 131.9±9.7 nm. Upon NIR irradiation, heat was generated and MTX release from HMM-Lipo was accelerated. Cell blocking experiments showed that HMM-Lipo was selectively internalized through CD44 receptor-mediated endocytosis. When HMM-Lipo was injected into the tail vein of collagen-induced arthritis (CIA) mice and exposed to a NIR laser (0.5 W/cm2, 3 min), swelling and redness of the inflamed area were alleviated. Thus, HMM-Lipo may provide high potential as an RA therapeutic agent for NIR-responsive chemo-photothermal therapy. |
| 저자 |
김민아, 정지윤, 신지의, 박지선, 윤순도, 이창문
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| 소속 |
전남대 |
| 키워드 |
Rheumatoid arthritis; chemo-photothermal therapy; NIR laser; therapeutic agents
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| E-Mail |
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