| 학회 | 한국공업화학회 |
| 학술대회 | 2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 | 24권 1호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | Cyclodextrin Incorporated Gelatin Bioglues to Reinforce Tissue Adhesiveness |
| 초록 | Bioglues are becoming promising materials in diverse clinical applications. However, to satisfy clinical requirements, the adhesiveness and biocompatibility have to be improved. In this study, Cyclodextrin (CD) incorporated gelatin-hydroxyphenyl (GH) hydrogels as a bioglue were developed to enhance the tissue adhesion property. The tissue adhesive strength of GH/CD hydrogels were significantly increased by incorporating CD into GH hydrogels via supramolecular forces. At GH 5 wt% and CD 5 wt%, the composite hydrogels exhibited maximum adhesive strength (36.5 kPa), which was nearly 3.3 and 8 times higher than that of GH hydrogels and fibrin glue as a control, respectively. Through in vitro cell study, we also confirmed that the GH/CD composite hydrogels have an excellent cytocompatibility. This shows an emerging potential as a promising tissue adhesive material. Acknowledgement: NRF-2018R1A2B2004529, 10062079 |
| 저자 | 박지슬1, Thai Thanh Hoang Thi1, 이윤기1, 박경민2, 박기동1 |
| 소속 | 1아주대, 2인천대 |
| 키워드 | Bioglues; Supramolecular forces; GH/CD; Adhesiveness |
