| 초록 |
We have developed pyrene modified magnetic polyaniline nanoparticles, a hybridization of MnFe2O4 magnetic nanoparticles (MNPs) and PANI using pyrene as a cross-linker for theranosis. In general, the strong affinity between PANI molecules due to the aromatic composition mediated π-π interaction and inter-chain hydrogen bonding hinder successful complex synthesis of PANI with other inorganic materials. To overcome this obstacle, we used pyrene as a cross linker to synthesize a stable complex of PANI with MNPs. We first modified the hydrophobic MNPs with pyrene via a hydrophobic interaction and then formed a complex with PANI. The pyrene induced π-π interaction between pyrene on the MNPs and PANI reduced the affinity between the PANI molecules and increased the strong affinity between PANI and MNPs, rendering stable nanocomplexes of MPANs. Finally, Cetuximab conjugated MPANs were fully tested for targeted theranosis in EGFR over-expressed cancer cells (A-431 cells) in-vitro. |
