| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Adhesion and proliferation of primary human fibroblasts on ligand-organized hydrogels |
| 초록 |
Cellular adhesion ligands in polymer scaffolds play a critical role in tissue engineering. An introduction of a specific ligand with the sequence of Arg-Gly-Asp (RGD) has been extensively exploited to enhance ligand-receptor interactions and control cell phenotype in tissue engineering. However, there are few studies regarding the effect of controlling the distance between adhesion ligands in polymer scaffolds in the nanometer size scale on the regulation of cell phenotype. In this study, we demonstrate that varying the distance between RGD peptides in alginate gels at the nanometer level can regulate phenotype of primary human fibroblasts. The approach of controlling the distribution and distance between cellular adhesion ligands at the nanometer level may be valuable in the design and tailoring of polymer scaffolds for tissue engineering applications. |
| 저자 |
배민수1, 이근용1, 박윤정2, David J. Mooney3
|
| 소속 |
1한양대, 2서울대, 3Division of Engineering and Applied Sciences |
| 키워드 |
adhesion ligand; alginate gel; fibroblast
|
| E-Mail |
|
