| 초록 |
To be an osteoinductive implant surface composition and roughness need to be carefully controlled in order to enhance a new bone formation and biomechanical stability. And bone healing is also improved by the administration of an osteogenic factors, such as bone morphogenetic protein 2 (BMP-2). But the efficacy of BMP-2 depends upon its mode of application. In this study, we hypothesize that application of BMP-2/CSA nanoparticles can promote the osteointegration of hydroxyapatite (HA)-coated titanium (Ti) implants with the surrounding bone. To identify the complexation of BMP-2 and CSA, this nanoparticle was characterized by using SEM, circular dichroism (CD), and zeta potential. The morphology of fabricated HA-coated titanium was determined using SEM, XRD, EDS, and ESCA. And the Ti surfaces are calcium-phosphate deposited for 7 and 14 days in vitro. The efficacy of nanoparticle is also evaluated using ELISA kit (R&D system). |
