| 학회 |
한국화학공학회 |
| 학술대회 |
2009년 봄 (04/23 ~ 04/24, 광주 김대중컨벤션센터) |
| 권호 |
15권 1호, p.355 |
| 발표분야 |
생물화공 |
| 제목 |
Enhanced production of fumaric acid by Rhizopus oryzae mutant |
| 초록 |
Fumaric acid is the chemical compound with the formula HO2CCH=CHCO2H. This white crystalline compound is one of two isomeric unsaturated dicarboxylic acids, the other being maleic acid wherein the carboxylic acid groups are cis. The commercial demand for fumaric acid has increased because of its extensive applications such as the food industry, the paper industry, the pharmaceutical industry and the feed industry. Fumaric acid can be produced by fungal fermentation and chemical synthesis. In the case of fungal fermentation, the production of fumaric acid has beenperformed by Rhizopus oryzae and Aspergillus niger. Recoverd spore of R. oryzae ATCC 20344 was treated with UV (5min)and successive γ-ray (7 KGy) according to the lethal rate of 99.9%. Mutants were selected based on the halo size in the selection medium and the production of fumaric acid was investigated in the submerged culture by R. oryzae mutants. Finally, R. oryzae RUR709 was selected and allowed for the increase in the production of fumaric acid from 14.9 to 23.4 g/L. |
| 저자 |
배양원1, 강성우2, 김승욱2, 전계택3, 조재훈4, 이도훈4, 김상용4, 박철환1
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| 소속 |
1광운대, 2고려대, 3강원대, 4한국생산기술(연) |
| 키워드 |
Rhizopus; fumaric acid; mutant
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| E-Mail |
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| 원문파일 |
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