| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
대학원생 구두발표 |
| 제목 |
Hyaluronic Acid - Gold Nanoparticle / Interferon α Complex for Target Specific Treatment of Hepatitis C Virus Infection |
| 초록 |
As an alternative to non-specific polyethylene glycol (PEG) conjugated interferon α (IFNα), target specific long-acting delivery system of IFNα was successfully developed using the hybrid materials of gold nanoparticle (AuNP) and hyaluronic acid (HA) for the treatment of hepatitis C virus (HCV) infection. The HA–AuNP/IFNα complex was prepared by chemical binding of thiolated HA and physical binding of IFNα to AuNP. According to anti-proliferation tests in Daudi cells, HA–AuNP/IFNα complex showed a comparable biological activity to PEG-Intron with a highly enhanced serum stability. Even after 7 days post-injection, HA-AuNP/IFNα complex was target specifically delivered and remained in the murine liver tissue, whereas IFNα and PEG-Intron were not detected. Accordingly, HA–AuNP/IFNα complex significantly enhanced the expression of OAS1 and Mx for innate immune responses to viral infection in the liver tissue, which was much higher than those by IFNα and PEG-Intron. |
| 저자 |
이민영1, 양정아2, 정호상2, 백송은2, 한세광2
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| 소속 |
1포항공과대, 2포항공대 |
| 키워드 |
Gold nanoparticle; Hyaluronic acid; Interferon α; Targeted delivery; Hepatitis C virus
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| E-Mail |
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