| 학회 |
한국고분자학회 |
| 학술대회 |
2003년 가을 (10/10 ~ 10/11, 부경대학교) |
| 권호 |
28권 2호, p.263 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Nanoimaging of Technetium-labelled Transferrin-conjugated Chitosan for Inflammation Site Diagnosis |
| 초록 |
The need to develop target-specific MRI contrast agents to aid disease diagnosis remains highly essential. Nearly 80 % of all radiopharmaceuticals used in nuclear medicine are 99mTc-labelled compounds. Therefore, 99mTc-labelled tranferrin-conjugated chitosan was developed and characterized as inflammation (or tumor)-targeted nanoimaging carrier. Technetium-labelled transferrin-conjugated chitosan (TTC) showed very high labeling efficiency of 99mTc stably for extended time. The TTC showed enhanced inflammation site contrast due to accumulation of transferrin-targeted white blood cell in the inflammation site. which was confirmed by conventional white blood cell staining method.
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| 저자 |
박인규1, 국승은1, 김은미2, 정환정2, 범희승3, T. Akaike4, 조종수1
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| 소속 |
1서울대 농생명공학부, 2원광대 핵의학과, 3전남대 핵의학과, 4동경공대 생체분자기능공학과 |
| 키워드 |
Nanoimaging; inflammation site; transferrin; chitosan
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| E-Mail |
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