| 학회 |
한국고분자학회 |
| 학술대회 |
2003년 봄 (04/11 ~ 04/12, 연세대학교) |
| 권호 |
28권 1호, p.339 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Nanoimaging of technetium-labelled Galactosylated Chitosan for Liver-specific Diagnosis |
| 초록 |
The need to develop target-specific MRI contrast agents to aid disease diagnosis remains highly essential. Nearly 80 % of all radiopharmaceuticals used in nuclear medicine are 99mTc-labelled compounds. Therefore, 99mTc-labelled galactosyl-methylated chitosan (GMC) nanoparticles were developed and characterized as liver-targeted nanoimaging carrier. GMC showed very high labeling efficiency of 99mTc stably for extended time (up to 3h). GMC showed enhanced hepatic contrast due to liver-specific uptake contrary to faint liver uptake of methylated chitosan (MC). Liver-targeted imaging of GMC indicated hepatic accumulation of GMC via specific interaction between galactose group of GMC and asialoglycoprotein receptors on the hepatocytes.
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| 저자 |
박인규;정환정;김은미;범희승;T. Akaike;조종수 |
| 소속 |
서울대 농생명공학부;원광대 의대 핵의학과;원광대 의대 핵의학과;전남대 의대 핵의학과;Department of Biomolecular Engineering |
| 키워드 |
Chitosan; Nanoimaging; Hepatocyte-targeting
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| E-Mail |
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