| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
대학원생 구두발표 (발표15분) |
| 제목 |
Intervertebral Disc Regeneration Using Stem Cell/Growth Factor-Loaded Porous Particles with a Leaf-Stacked Structure |
| 초록 |
Although biological therapies based on growth factors and transplanted cells have demonstrated some positive outcomes for intervertebral disc (IVD) regeneration, repeated injection of growth factors and cell leakage remain as challenges for human applications. Herein, we prepare human bone marrow-derived mesenchymal stem cells (hBMSCs) and transforming growth factor-β3 (TGF-β3)-loaded particles with a leaf-stacked structure throughout the entire matrix (LSS), as a combination bioactive delivery for degenerated IVD. The LSS particles allow sustained release of TGF-β3 and stable cell adhesiveness. On the basis of in vitro and in vivo studies, it was observed that the hBMSCs/TGF-β3-loaded LSS particles can provide an appropriate environment for chondrogenic differentiation of hBMSCs and induces IVD regeneration in a beagle dog model. Thus, therapeutically loaded LSS particles offer the promise of an effective bioactive delivery system for regeneration of various tissues including IVD. |
| 저자 |
김민지1, 이진호2, 김준수3, 김호용1, 이희천3, 변준호3, 이재훈3, 김나현4, 오세행1
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| 소속 |
1단국대, 2한남대, 3경상대, 4안전성평가(연) |
| 키워드 |
Intervertebral disc (IVD); IVD regeneration; Microparticles; human bone marrow-derived mesenchymal stem cells (hBMSCs); growth factor; Tissue engineering
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| E-Mail |
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