| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 가을 (11/03 ~ 11/05, 대구 엑스코(EXCO)) |
| 권호 |
25권 2호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Highly Sensitive Near-Infrared SERS Nanoprobes for in vivo Imaging using Gold-assembled Silica Nanoparticles with Controllable Nanogap |
| 초록 |
In this study, gold (Au)-assembled silica (SiO2) nanoparticles (SiO2@Au@Au NPs) as NIR SERS nanoprobes were synthesized by using seed-mediated growth method. The SiO2@Au@Au NPs were prepared by controlling the Au precursor in the growing step. As a result, surface plasmonic band SiO2@Au@Au NPs the nanogaps between Au NPs on the SiO2 surface can be controlled from 4.16 to 0.98 nm which generate SERS hotspots. SiO2@Au@Au NP with 0.98 nm gap showed the high SERS signal under 785 nm excitation (enhancement factor ~ 3.8×106). SiO2@Au@Au nanoprobes were detectable in vivo SERS signals with 16 μg/mL in a 7 mm deep in animal tissue. SiO2@Au@Au NPs with 14 different Raman label compounds have distinguishable SERS signals while subcutaneously injection into nude mice, which shows having potentials to be used as a multiplex nanoprobe for in vivo applications. |
| 저자 |
복성재, 김윤희, 김우연, 함경민, 전봉현
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| 소속 |
건국대 |
| 키워드 |
Surface enhanced Raman spectroscopy; gold nanoparticle; nanogap; hotspot; in vivo imaging
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| E-Mail |
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