| 초록 |
Posterior capsular opacification(PCO) is the most common complication of cataract surgery. PCO is due to the proliferation, migration, and epithelial-to-mesenchymal transition of the residual lens epithelial cells(LECs) within the lens capsule. As surface topography influences cellular response, we investigated the effect of modulating the dimensions of periodic patterns on the surface of an intraocular lens material to regulate LECs functions. Samples were patterned using a femtosecond laser, and the behaviors of LECs were observed on patterns. In the presence of ridge and groove patterns, the adherent cells elongated along the direction of the patterns. Cell migrations were inhibited in the perpendicular direction of the patterns. In vivo results showed that a patterned IOL could help suppress the progression of PCO. Our reports demonstrate that topographical patterns on a biomaterial surface can regulate cellular behavior when it is implanted into animals. |
