| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
The Inflammatory Responses on Hyaluronic Acid Loaded PLGA Scaffold fabricated by Emulsion Freeze-Drying Method |
| 초록 |
PLGA has been widely applied to tissue engineering as a good biocompatible material. However, their acidic degradation products can decrease the pH in the surrounding tissue, which result in local inflammatory reaction. We hypothesized that the cells neighboring the PLGA implant might have an inflammatory response which could be reduced by impregnating HA into the PLGA. To evaluate the influence of HA content in PLGA materials on cell viability. PLGA/HA scaffolds for the in vivo study were implanted in Wister rates for 5 days. Cell proliferation activity was measured using WST assay. ELISA for TNF-α was conducted to evaluate the inflammatory response of cells on the PLGA/HA scaffolds. Fibrous wall thickness and macrophage were evaluated by H&E and ED-1 immunohistochemical staining, respectively. We concluded that HA could reduce inflammatory response of PLGA. This research was supported by WCU(R31-20029) and MBC (0405-B001-0204-0006). |
| 저자 |
배지연, 서한솔, 김수진, 이윤미, 송정은, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
hyaluronic acid(HA); PLGA; inflammatory responses
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| E-Mail |
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