화학공학소재연구정보센터
학회 한국공업화학회
학술대회 2019년 봄 (05/01 ~ 05/03, 부산 벡스코(BEXCO))
권호 23권 1호
발표분야 콜로이드·계면화학_포스터
제목 Mechanically Robust Multilayered Emulsion Films for Thermosensitive Drug Delivery Adhesive Patches
초록 In this study, we introduce a temperature-responsive novel nanoemulsion film (NEF) system. The NEFs were fabricated by alternative layering of nanoemulsion with bacterial cellulose nanofibirils (BCNFs) through the layer-by-layer deposition. Basically, the NEFs reinforced with BCNFs showed more increased moduli than those with polyelectrolytes only, which stems from the mechanical properties of BCNFs. The NEFs fabricated in this study exhibited a typical Spinodal decomposition behavior. We could observe that when heat is applied to the NEF, the nanoemulsion drops uniformly diapered in the 3D network structure of BCNF readily interdiffused to form the oil domains. Thus, this behavior of BCNFs resulted in the drastic decrease in the phase separation rate and formation of smaller oil domains. Finally, we demonstrated that the NEFs could be used not only for development of a patch-type drug delivery system, but also for the development of a temperature-responsive novel adhesive film.
저자 박예진, 신경희, 서혜민, 김진웅
소속 한양대
키워드 emulsion films; bacterial cellulose nanofibrils; Spinodal decomposition; drug delivery; adhesive patches
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