| 초록 |
The reaction of ethyl-4,4-difluoro-2-iodo-5-oxo-5-phenylpentanoate(2) with primary amines in one-pot scheme produced a series of b-fluoropyrrole derivatives at ambient temperatures. In this reaction, the less bulky the primary amine is, the higher the yield resulted. When (2) and aqueous methylamine(40%) were allowed to react below 0 oC, 5-(ethoxycarboxyl)-1-methyl-3,3- difluoro-2-hydroxy-2-phenylpyrrolidine, an intermediate molecule for 2-ethyl-4-flouro-1-methyl- 5-phenylpyrrole-2-carboxylate(5), was isolated first. |
