| 초록 |
Thrombus, major life-threatening vascular diseases, is mainly composed of fibrin and activated platelets which have a high level of ROS, especially H2O2. In this work, we synthesized thrombus-specific theranostic (T-FBM) nanoparticles which could scavenge over-expressed H2O2 and release bioactive hydroxybenzyl alcohol (HBA). T-FBM nanoparticles were also designed to be activated by H2O2 to generate CO2 bubbles which could amplify photoacoustic signal through thermoelastic expansion of photoabsorbers and vaporization without the use of external pulsed laser. In vivo studies, T-FBM nanoparticles exerted antioxidant and anti-thrombotic effects by suppressing the formation of thrombus. In addition, T-FBM nanoparticles showed significant amplification of photoacoustic signals specifically in thrombosed vessels. We therefore anticipate that T-FBM nanoparticles hold great translational potential as theranostic agents for H2O2-related diseases. |
