| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
In Situ Forming Smart Supramolecular Hydrogels for Long-term Bioengineered Stem Cell Therapy |
| 초록 |
Synthetic hydrogels have been extensively investigated as artificial extracellular matrices for tissue engineering. Crucial challenges for such hydrogels are sustaining long-term cytocompatible encapsulation and providing appropriate cues at the right place and time for spatio-temporal control of the cells. Here, we report in situ supramolecularly assembled and modularly modified hydrogels for long-term engineered mesenchymal stem cell (eMSC) therapy using cucurbit[6]uril conjugated hyaluronic acid (CB[6]-HA), diaminohexane conjugated HA (DAH-HA), and drug conjugated CB[6] (drug-CB[6]). The eMSCs alive within CB[6]/DAH-HA hydrogels in mice for more than 60 days. Furthermore, the long-term expression of interleukin-12 by eMSCs within the supramolecular hydrogels resulted in inhibition of tumor growth with a significantly enhanced survival rate. Taken together, our findings confirm the feasibility of supramolecular hydrogels as 3D artificial ECMs for tissue engineering applications. |
| 저자 |
염준석, 김수진, 정현태, 남궁홍, 양정아, 김기문, 성영철, 한세광
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| 소속 |
POSTECH |
| 키워드 |
Hyaluronate; Cuccurbituril; Hydrogel; Host-guest chemistry; Stem cell; Cancer therapy
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| E-Mail |
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