| 초록 |
This presentation will focus on in vitro model systems aimed at representing the human organs. Well-based cell culture models do not properly represent the physiology of the human tissues and organs. Microfluidics technology has contributed to the development of organ-on-a-chip, which tries to replicate the in vivo tissue microenvironment. Another limitation of cell culture models is that they only represent single tissue type, so cannot capture the dynamic interaction between different organs. This poses a significant limit, because many physiological processes are orchestrated by intricate communication and interaction between different tissues and organs. The main goal of our research is to use microfluidic technology to develop in vitro model systems that can recapitulate complex physiological processes between multiple organs. We incorporate different cells, such as the gut, liver, kidney cells in our multi-organ-on-a-chip to allow interaction between the organs and observe the resulting dynamics of drugs. |
