| 초록 |
Detecting neurotransmitters is critical in the prognosis of neurodegenerative diseases. Recently, Mxene draws significant attention due to its superior electrical properties. However, functionalizing the surface of MXene to immobilize biomolecules is challenging, which hinders MXene from being utilized for wide biosensing applications. Here, we developed aptamer-based MXene biosensors to detect neurotransmitters by depositing ultrathin (＜ 10 nm) polymers on top of MXene. A poly(hexavinyldisiloxane)(pHVDS) was directly applied on MXene via iCVD to functionalize Mxene with vinyl moeity . The vinyl group was utilized for bonding thiolated aptamers via a thiol-ene reaction. A successful thiol-ene reaction was confirmed via AFM, XPS, and WCA. We also observed the I-V curves of MXene changed as concentrations of neurotransmitters in aqueous condition, infers that the aptamer-conjugated MXene we demonstrated can be further utilized to detect the neurotransmitters selectively. |
