| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Glycol Chitosan-Based Nanocomplexes as a Sustained Delivery System of Exendin-4. |
| 초록 |
Exendin-4, a long-acting GLP-1 agonist, has considered to be more effective than native GLP-1. However, the clinical effectiveness of exendin-4 has been limited by its short biological half-life. Therefore, the long-acting formulation of exendin-4 still remains an interesting challenge. Owing to strong binding of lithocholic acid to ß-cyclodextrin(ß-CD), it was expected that supramolecular systems based on ß-CD could further extend the drug’s duration of action. To comprehend our concept, we have synthesized glycol chitosan bearing ß-CD(ß-CDGC) conjugate and investigated their complexation behavior with LAM1-Ex4. The physicochemical characteristics of nanocomplexes were investigated. Further, db/db mice were administered a single subcutaneous injection of LAM1-Ex4/ß-CDGC nanocomplexes and blood glucose levels were monitored using a glucometer and tail-tip blood samples. The results indicate that nanocomplexes had a potential as a long-acting formulation of exendin-4. |
| 저자 |
장혜진, 손소희, 채수영, 이강춘, 조동규, 박재형
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| 소속 |
성균관대 |
| 키워드 |
Cyclodextrin; Exendin-4; Antidiabetic
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| E-Mail |
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