| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Local and Sustained Delivery of Dual Growth Factor (bFGF/NGF) for Urethral Sphincter Muscle and Nerve Regeneration |
| 초록 |
We, previously reported the heparin-Pluronic (HP) nanogels-embedded gelatin-poly(ethylene glycol)-tyramine (GPT) hydrogel prepared using horseradish peroxidase (HRP)-catalyzed reactions of aqueous GPT solutions containing HP nanogels for tissue regeneration. In this study, dual growth factor (bFGF/NGF) delivery using hybrid hydrogel system has been performed and in vitro evaluations have been studied. FGF loaded HP nanogels were prepared by direct dissolution method. After bFGF encapsulation, the average size of the HP nanogels was increased from 90 to 150 nm. We prepared GPT which was containing bFGF loaded HP nanogels and NGF using simple mixing. Growth factors were sustainedly released from the gel matrix over 1 month and the released growth factors amounts could be controlled by changing growth factor loading amounts. The obtained results support that our dual growth factor-carrying hybrid hydrogel system have great potential in regenerating urethral sphincter muscles and nerves. |
| 저자 |
손주영, 박경민, 박기동
|
| 소속 |
아주대 |
| 키워드 |
Dual growth factor delivery; Heparin nanogel; Gelatin hydrogel
|
| E-Mail |
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