| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Chitosan sponge as a scaffold for skin tissue engineering and a dermal substitute |
| 초록 | It was the aim of this study to evaluate chitosan sponge as a scaffold for skin tissue engineering and a dermal substitute in burn wound. The used chitosan sponge made from the chitosan (CS) or the acetylated chitosan (ACS) was coated with 0.1 % type I collagen or not. Deep second degree burn (3X6 cm) was created on the back of pig (n=11) and the full-thickness skin defects were made after 7 days. Integra, Terudermis, CS, ACS, CS coated with type I collagen, and ACS coated with type I collagen were immediately grafted in the wound bed. On day 14 after surgery, 0.025 inch-thick auto-skin was grafted on them. Grafts were evaluated grossly and histologically on day 7, day 14, day 21 after surgery. In all cases, the wounds were closed by the reconstruction of neodermis and successful take of auto-skin graft. Angiogenesis in the upper region of artificial dermis was observed within 14 days after overlaying of artificial dermis. After auto-skin graft, the rete ridges structure was well constructed in all case. The fragments of CS and ACS with or without Type I Collagen coating were present only in the upper regions of neodermis. In summary, this study suggests that the chitosan sponge will be a scaffold for skin tissue engineering and a dermal substitute to replace the collagen based dermal substitute. ACKNOWLEDGEMENT : This work was supported by grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea. |
| 저자 | 최영주1, 손대구2, 황지훈1, 박기숙1, 김현지2, 손형빈2, 손영숙3, 김천호3, 박찬웅1 |
| 소속 | 1(주)모던티슈테크놀리지, 2계명대, 3원자력의학원 생체조직재생연구실 |
| 키워드 | dermal substitute; chitosan sponge |
