| 학회 | 한국고분자학회 |
| 학술대회 | 2003년 봄 (04/11 ~ 04/12, 연세대학교) |
| 권호 | 28권 1호, p.257 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Preparation and Characterization of Solid Dispersion of Poorly Water Soluble Drug, Acyclovir |
| 초록 | A solid Dispersion is the dispersion of poorly water-soluble drugs in water-soluble inert polymeric carriers and has been widely used to enhance the bioavailability of poorly water-soluble drugs and there are two methods to prepare solid dispersions-co melting method and solvent evaporation method. We prepared solid dispersions of acyclovir using two method, spray drying method and freeze drying method varying the composition of drug and hydrophilic polymer. SEM, XRD, DSC were used to evaluate the physicochemical properties and solid dispersions and dissolution test was conducted to investigate the release pattern of solid dispersed acyclovir tablets. Acknowledgement: This work was supported by KOSEF (Grant NO: R01-2001-00431) |
| 저자 | 안용산;양대혁;송인범;김정훈;이종문;강길선 |
| 소속 | 전북대 |
| 키워드 | Solid Dispersion; Acyclovir; Acetic Acid; Dissolution Rate |
