| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 봄 (05/02 ~ 05/04, 여수 엑스포 컨벤션) |
| 권호 |
20권 1호 |
| 발표분야 |
생물공학_포스터 |
| 제목 |
Near infrared fluorescence-encoded lipid supported polymeric particle system for stem cell in vivo imaging |
| 초록 |
Imaging the grafted stem cell and monitoring their migration or differentiation in in vivo condition is important to make better understanding on stem cell therapeutics. Several conventional imaging tools are already developed. However, it is very important to make non-toxic and non-invasive imaging strategy because of the nature of stem cell than the other differentiated cells. In this aspect, we designed a novel near infrared fluorescence color-encoded light-emitting lipid-supported polymeric particulate (NLP). The lipid composition of NLP was maleimide functionalized to make a covalent bond with thiol group on the cell surface proteins, which can minimize the interaction with metabolic components and genomic damages. Core polymeric particulate contains indocyanine green fluorescent dye for efficient in vivo imaging. We propose that this NLP-tagging system has a significant potential for stem cell imaging and further applications in stem cell-based therapeutics. |
| 저자 |
신우정, 신승원, 송인현, 엄숭호
|
| 소속 |
성균관대 |
| 키워드 |
stem cell imaging; near infrared imaging; lipid supported plga nanoparticle
|
| E-Mail |
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