| 초록 |
Light-emitting organisms have been extensively studied along with their diverse phylogenetic distribution patterns and disparate biochemical systems. With inspiration from such organisms, there have been several attempts to make efficient diagnostics with ecological light-emitting systems derived from marine environments and organisms. Motivated by bio-inspired engineering, we designed novel fluorescence color-encoded light-emitting lipid-supported polymeric particulate resembling fluorescent or luminescent bacteria externally. The particulate was composed of three subdivisions including an outer liposome, a polymeric matrix medium, and a core DNA-fluorescent dye complex. The cores were labeled with blue, green, yellow, and red for potential multiplexing. The fluorescence-emitting particulate was practically used for both in vitro and in vivo selective cancer diagnostic imaging. We propose that use of this synthetic light emitting particulate enables flexible diagnostic imaging. |
