| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Multi-functional Porous PCL Microspheres for Effective Osteogenic Differentiation and Anti-microbial Efficacy |
| 초록 |
Sustained release of growth factor from delivery systems is a commonly accepted strategy for maintaining their long-term bioactivity and safety. Antibiotics have been used to treat a number of bacterial infections. In this study, we fabricated a BMP-2 (growth factor)/vancomycin (antibiotic)-loaded polycarprolactone (PCL)/hyaluronic acid (HA) hybrid microspheres to be used as a bioactive bone graft material. The prepared PCL/HA microspheres had a sub-micron-sized pores on the outer surface and micron-sized inner pore structure. The PCL/HA microsphere showed the sustained release of both BMP-2 and vancomycin. From the in vitro stem cell differentiation and anti-bacterial tests, it was observed that both BMP-2 and vancomycin-loaded PCL/HA microsphere group showed better osteogenic differentiation of hBMSCs and anti-microbial efficacy than the microsphere groups without BMP-2 or vancomycin as well as the groups with single BMP-2 or vancomycin. |
| 저자 |
장희윤1, 신준영1, 김세현1, 김민지2, 곽유진1, 이인수1, 오세행2, 이진호1
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| 소속 |
1한남대, 2단국대 |
| 키워드 |
Polycarprolactone; Hyaluronic acid; Microsphere; BMP-2; Vancomycin
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| E-Mail |
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