| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Spinal cord Regeneration Using Bone Marrow Stromal Cell with PLGA/DBP Nerve Channel Contained Alginate |
| 초록 |
Bone marrow stromal cells (BMSCs) exhibit multiple traits of a stem cell population. We proposed to use Poly(L-lactide-co-glycolide) (PLGA) nerve channel impregnated with Demineralized bone particle (DBP) and alginate by tissue-engineering principles for the repair of spinal cord injury. The spinal cord was completely transected horizontally at two levels (T7 and T8) and PLGA/DBP nerve channel seeded the cells were implanted in the lesion. For histological and immunochemical evaluation, the implants were removed after 2, 4 and 8 weeks and then stained by H&E and anti-NF. Motor functional outcome measurements using the BBB scoring, sensory test and motor functional recovery test were performed every week for 8 weeks post injury. This study suggested that BMSCs and alginate containing PLGA/DBP nerve channel may have an important role for spinal cord regeneration of tissue engineering area. |
| 저자 |
김혜민, 고현아, 심초록, 이정환, 송정은, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Bone marrow stromal cell; PLGA; DBP; Spinal cord; Alginate
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| E-Mail |
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