| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Dissolution Behavior of Losartan Mixture Composed of Various Excipients |
| 초록 |
The object of this study is to identify the dissolution behavior of losartan made by various excipients. Losartan mixtures were prepared by direct compression. Characterization of losartan mixtures was analyzed by using various equipments such as SEM, DSC, XRD and FT-IR. SEM was used to analyize the surface morphology of drug, excipients and loasartan mixture. FT-IR was used to demonstrate characterization of excipients and hydrogen bonding of losartan mixture between drug and excipients. The degree of crystallinity and melting point made by interatction was demonstrated by using DSC and XRD. In vitro dissolution behavior of losartan mixtures was experimented in simulated intestinal juice(pH 6.8) and this results were compared with commercial drug(Losarplus®). The dissolution rate of all control group were changed because of influence of excipients. This study suggests that the type of excipients added in mixture can effect the dissolution behavior and change dissolution rate of drug. |
| 저자 |
이정환, 배정우, 심초록, 조선아, 고현아, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Dissolution behavior; Losartan; Mixture; Excipient
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| E-Mail |
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