| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 봄 (04/10 ~ 04/11, 컨벤션 뷰로(대전)) |
| 권호 |
33권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Characterization of Novel Thermosensitive and Biocompatible Pluronic F127 Derivatives for Cartilage Tissue Engineering |
| 초록 |
Thermogelling Pluronic F127 has been studied extensively as a biocompatible material for drug delivery system and tissue engineering. In this study, we synthesized novel temperature-sensitive, biocompatible Pluronic F127 derivatives, and Gly-Arg-Gly-Asp (GRGD) peptide was then grafted to F127-4-methacryloxyethyl trimellitic anhydride (FM), F127-glycolide-4-methacryloxyethyl trimellitic anhydride (FGM) respectively. These functional polymers were characterized by FTIR, 1H-NMR, 13C-NMR, GPC and dynamic mechanical analysis. Cytotoxicity of the polymers was evaluated in cell viability of chondrocytes using trypan blue dye exclusion assay. |
| 저자 |
최보규1, 박귀덕1, 안광덕1, 정병문2, 한동근1
|
| 소속 |
1한국과학기술(연), 2이화여자대 |
| 키워드 |
Tissue Engineering; Thermosensitivity; Pluronic F127 derivatives; RGD; chondrocytes
|
| E-Mail |
|
