| 학회 | 한국고분자학회 |
| 학술대회 | 2003년 가을 (10/10 ~ 10/11, 부경대학교) |
| 권호 | 28권 2호, p.379 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Dissolution test of ibuprofen using the self micro-emulsifying drug delivery system (SMEDDS) |
| 초록 | The quick efficiency and long term delivery are important things in drug delivery system. In this work, model drug ibuprofen (non-steroid antiphlogistic anodyne) uses SMEDDS for enhancing solubility and rapid efficiency. SMEDDS composed of carbitol (co-surfactant), 1944cs (oil) and RH-40 (surfactant). Ibuprofen has low solubility in water (0.03~2.5㎎/㎖) but dissolves in oils and surfactants. Drug is solved with carbitol, then mix 1944cs and RH-40. We found out the most suitable combination rate which was formed micell by annexing water. Phase diagram draw up a degree of micell formation. Ingredients except water from the mixture are compared with two commercial reference sirup which was established as contrast group. Dissolution test was performed by three hours. The result is that both experiment group and contrast group were observed about 70% dissolution degree in gastric juice while the former was observed about 80% high dissolution behavior in contrast with the latter which was dissoluted about 10% in intestinal juice. Therefore this work suggest quick pharmacological action because the first dissolution rate of the drug is high that antiphlogistic anodyne must make it ready. Acknowledgement: This work supported by KOSEF(R01-2001-00431) |
| 저자 | 안용산1, 양대혁1, 홍금덕1, 송지희1, 강복기1, 이종문1, 조선행2, 이해방2, 강길선1 |
| 소속 | 1전북대, 2한국화학(연) |
| 키워드 | ibuprofen; SMEDDS |
