| 학회 | 한국고분자학회 |
| 학술대회 | 2002년 가을 (10/11 ~ 10/12, 군산대학교) |
| 권호 | 27권 2호, p.313 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Study on the effects of gamma irradiation on PLGAs |
| 초록 | Poly(D,L-lactide-co-glycolide) (PLGA) is moisture and heat sensitive polymer, so it is good candidate for gamma sterilization. The gamma irradiation doses were 0, 2.5, 5 and 7.5 Mrad. The molecular weight of PLGAs were 50:50 copolymer with 33,000 (Resomer RG 503H) and 110,000 (Resomer RG 506) and 75:25 copolymer with 20,000 (Resomer RG 752) and 90,000 (Resomer RG 756) g/mole. The effect of gamma irradiation on PLGA molecular weight was evaluated by gel permeation chromatography (GPC). Differential scanning calorimetry (DSC) , electron spin resonance (ESR) and fourier transform infra-red (FT-IR) were performed on untreated and gamma irradiated PLGA. The molecular weight and Tg of PLGAs decreased with increasing the gamma irradiation doses. Mechanism of degradation with different lactide/glycolide ratio and different doses were discussed in terms of changes of MW, MWD and Tg. Study on the storage effect of PLGA after gamma irradiation is in progress. Acknowledgment: This work was supported by KMOCIE(B49-990-5411-05-1-3) |
| 저자 | 이진수1, 공종수2, 안태군3, 강길선, 이종문*, 이해방** |
| 소속 | 1전북대, 2*전북대, 3**한국화학(연) |
| 키워드 | PLGA; gamma irradiation; molecular weight |
