| 학회 | 한국공업화학회 |
| 학술대회 | 2016년 봄 (05/02 ~ 05/04, 여수 엑스포 컨벤션) |
| 권호 | 20권 1호 |
| 발표분야 | 생체재료_포스터 |
| 제목 | Modofication of RGD to MPEG-PCL and its effects on osteogenic differentiation of MSCs |
| 초록 | Mesenchymal stem cell (MSC) transplantation has showed up as a promising therapy for regenerative medicine. However, it is limited by low grafted cell retention and survival within the damaged tissues. We investigated the effects of Arg-Gly-Asp (RGD) modified methoxy poly(ethylene glycol)-poly(caprolactone) (MPEG-PCL). The RGD Cell adhesion to RGD is mostly mediated by two integrin receptors –α5β1and α2β1. Over a 3 day observation period, cell proliferation was increased when cells were cultured into MPEG-PCL-RGD. Moreover, expressions of α5β1and α2β1 were upregulated in MPEG-PCL-RGD. These results demonstrate that RGD immobilized MPEG-PCL performs synergistically with MSCs to enhance osteogenic differentiation. These findings suggest potential use for RGD-modified MPEG-PCL as a scaffold in the field of tissue engineering and bone regeneration. Acknowledgment : This research was supported by the grant of ministry of Trade, Industry and Energy(MOTIE) (Grant no. 10047811) |
| 저자 | 김현주, 양대혁, 하미연, 배철민, 전흥재 |
| 소속 | 가톨릭대 |
| 키워드 | MPEG-PCL; RGD; MSC; osteogenic differentiation |
