| 학회 | 한국공업화학회 |
| 학술대회 | 2016년 봄 (05/02 ~ 05/04, 여수 엑스포 컨벤션) |
| 권호 | 20권 1호 |
| 발표분야 | 생체재료_포스터 |
| 제목 | Preparation and characterization of self-assembled paclitaxel-conjugated MPEG-PCL nanoparticles |
| 초록 | In this study, PTX-conjugated methoxy poly(ethylene glycol)-b-poly(ε-caprolactone) (PTX-MPEG-PCL) was utilized to improve the water-solubility of PTX. MPEG-PCL was prepared by ring-opening polymerization of poly(ε-caprolactone) (PCL) with methoxy polyethylene glycol (MPEG, 750 g/mol) as an initiator. The hydroxyl terminal group of MPEG-PCL was substituted to a carboxyl terminal by succinic anhydride (SA), after which PTX was conjugated to MPEG-PCL by esterification via condensation reaction, confirmed by 1H NMR. PTX-MPEG-PCL was self-assembled above 2.8 × 10-5 mg/ml analyzed by fluorescence spectroscopy. The self-assembled PTX-MPEG-PCL showed a spherical morphology with a size distribution ranging from 40 to 460nm (DLS and TEM). Acknowledgment : This research was supported by the grant of ministry of Trade, Industry and Energy(MOTIE) (Grant no. 10047811) |
| 저자 | 이윤성, 김태형, 양대혁, 배철민, 전흥재 |
| 소속 | 가톨릭대 |
| 키워드 | MPEG-PCL; Paclitaxel; Nanoparticle; H NMR; Fluorescence spectroscopy; TEM; DLS |
