| 학회 | 한국공업화학회 |
| 학술대회 | 2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 22권 2호 |
| 발표분야 | 생체재료_포스터 |
| 제목 | Efficacy of visible light-cured glycol chitosan hydrogels containing inclusion complex between beta-cyclodextrin and curcumin on accelerated wound healing |
| 초록 | In the present study, visible light-cured glycol chitosan (GC) hydrogel systems containing inclusion complex between beta-cyclodextrin (ß-CD) and curcumin (CUR) for the sustained release of CUR were prepared, and their efficacies in wound healing acceleration were investigated in vivo. The in vivo wound healing efficacies of the hydrogels were extensively investigated using a mouse excisional wound model. A decrease in the macroscopic appearances was observed on the wounds treated with ß-CD-ic-CUR/GC, as compared to untreated or CUR/GC-treated wounds. Also, ß-CD-ic-CUR/GC-treated wound showed increased collagen synthesis. These results provide evidence that improving the water-solubility of CUR contributes to acceleration of wound healing. ACKNOWLEDGMENTS Ministry of Trade, Industry and Energy (MOTIE) (Grant no. 10047811 & 10053595) and the Basic Science Research Program through the National Research Foundation of Korea (NRF) (2017R1D1A1B003033195) |
| 저자 | 양대혁1, 김재광1, 김천호2, 전해명1, 전흥재1 |
| 소속 | 1가톨릭대, 2한국원자력의학원 |
| 키워드 | Glycol chitosan hydrogel; Visible light irradiation; Curcumin; Beta-cyclodextrin; Wound healing |
