| 학회 | 한국공업화학회 |
| 학술대회 | 2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 23권 2호 |
| 발표분야 | 포스터_생체재료 |
| 제목 | Optimization of cRGDfK Ligand Concentration on Polymeric Nanoparticles to Maximize Cancer Targeting |
| 초록 | We prepared fluorescent cyanine 5.5 dye and cyclo(arginine-glycine-aspartic acid-phenylalanine-lysine) ligand-modified polyethylene glycol-poly(lactic-co-glycolic acid) (Cy 5.5-cRGDfK-PEG-PLGA) NPs with different ligand concentrations and investigated their cancer-targeting abilities in vivo. In vivo, NPs with 6 w/w%cRGDfK concentration showed prolonged uptake by the cancer tissue during the 7-day test period. These results suggest that Cy 5.5-cRGDfK6-PEG-PLGA NPs could serve as valuable drug carriers and diagnostic agents for the clinical treatment and targeting of solid cancers. Acknowledgment: This work was supported by the Ministry of Trade, Industry & Energy (MOTIE, Korea) (20003560 and 20004627) and by the National Research Foundation of Korea (NRF) (2017R1D1A1B03033195) of Korea. |
| 저자 | 양대혁, 윤이현 |
| 소속 | 가톨릭대 |
| 키워드 | cRGDfK ligand; polymeric nanoparticles; cancer targeting |
