| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 봄 (04/07 ~ 04/09, 대전컨벤션센터) |
| 권호 |
46권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 Ⅰ |
| 제목 |
Study on anti-thrombotic properties using zwitterionic and tetra-fluorinated polyurethane-based surface-modifying oligomers |
| 초록 |
To prevent the anti-thrombosis and the bacterial biofilm formation, zwitterionic or fluorinated macromolecules have been proposed as a surface-modifying oligomer (SMO) for the surface modification of polymeric biomaterials. In this study, novel oligomers with zwitterionic and tetra-fluorinated polyurethane backbones (ZFPU) were synthesized and blended with polyvinyl chloride (PVC) to evaluate anti-fouling and anti-thrombotic effects. 1H NMR and FT-IR have demonstrated that zwitterionic groups and tetra-fluorinated segments were successfully introduced to the ZFPU backbone. We also investigated the protein adsorption, platelet adhesion and the wettability of ZFPU/PVC films. These results demonstrated that the surface of ZFPUs-blended PVC significantly suppresses the protein adsorption and the platelet adhesion/activation compared to those of the pristine PVC. It is expected that our novel SMOs will have high hope for blood-contacting medical devices. |
| 저자 |
최수연, 양승원, 임충만, 강종희, 정윤기
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| 소속 |
한국과학기술(연) |
| 키워드 |
Keywords: surface-modifying oligomer; zwitterionic oligomer; fluorinated oligomer; anti-fouling; anti-thrombotic property; polyurethane
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| E-Mail |
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