| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 가을 (11/03 ~ 11/05, 대구 엑스코(EXCO)) |
| 권호 |
25권 2호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Development of monofilamentous stent with biodegradable PLLA-PDO core-sheath fiber for nonvascular implantation |
| 초록 |
For its high flexibility and biocompatibility polydioxanone (PDO) has benn widely used in bio-medical fields. But, such as low mechanical stability during degradation and etc. has been noticed as drawbacks for PDO stent. In this investigation, PLLA-PDO core-sheath monofilament based stent are designed to optimize mechanical properties, biodegradability, and drug release. Decrement of tensile strength, elastic modulus, and elongation properties were delayed in the PLLA-PDO monofilament degradation process comparing to the PDO monofilament. Dexamethasone was added in the PLLA-PDO monofilament for drug release. Degradation behavior between dexamethasone-loaded PLLA-PDO monofilament and bare PLLA-PDO monofilament were not observed. Also, we were able to observe sustained release of dexamethasone form PLLA-PDO monofilaments. In general, our drug-eluting sheath-core monofilament stents can be a promising model for advanced non vascular implantation. |
| 저자 |
양승원1, 정윤기1, Cheol-Min Han1, Eugene Lih1, Seul-Ki Choi1, 한동근2, 손준식3
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| 소속 |
1한국과학기술(연), 2차병원, 3한국섬유(연) |
| 키워드 |
core-sheath monofilament; drug-eluting stent; polydioxanone; poly (L-lactic acid)
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| E-Mail |
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