| 학회 | 한국공업화학회 |
| 학술대회 | 2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 26권 1호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | Study of dexamethasone loaded biodegradable PLLA-PDObiphasic monofilament for nonvascular stent application. |
| 초록 | Biodegradable polymeric filaments were recognizedfor usage in biomedical applications. However, problems such as inflammationand mechanical properties are still remaining. In our recent study, poly(L-lactide)-polydioxanone(PLLA-PDO) core-sheath monofilaments have been developed and characterized. Inthis research, dexamethasone (DEX) widely known drug for anti-inflammatorytraits were loaded to PLLA-PDO core-sheath monofilaments. Mechanicalproperties, biodegradability, and the drug release were investigated. Improvementof mechanical properties in the degradation process were shown due to thebiphasic structure of monofilaments and biodegradation of monofilaments couldbe controlled by biphasic structure and drawing process. Drug release ofPLLA-PDO monofilaments showed sustain or controlled manners by location of drugand drawing rates. To sum up, our drug-eluting sheath-core monofilaments arepromising model for advanced nonvascular stents. |
| 저자 | 양승원1, 정윤기1, 손준식2, Myoung Jin Jang2 |
| 소속 | 1한국과학기술(연), 2Korea Textile Development Institute |
| 키워드 | core-sheath monofilament; drug-eluting stent; polydioxanone; poly (L-lactic acid) |
