| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 봄 (04/07 ~ 04/09, 대전컨벤션센터) |
| 권호 |
46권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 Ⅰ |
| 제목 |
Painless transdermal delivery of therapeutic peptides for the treatment of scleroderma |
| 초록 |
Peptide drugs are important biologic therapeutics used for the treatment of various diseases. However, owing to short in vivo half-life, frequent peptide injections using invasive hypodermic syringes are required to produce successful therapeutic outcomes. Here, we present a microneedle (MN)-assisted transdermal delivery of peptides for long-acting. For this purpose, therapeutic peptides for the treatment of scleroderma were precisely coated on the biodegradable bullet-shaped MN arrays and their loading efficiency was evaluated through dissolution tests of coated MNs. Aqueous coating solutions including peptides were coated with high precision and accuracy. An in vivo pilot study using scleroderma animal model showed prolonged retention of peptides delivered by MNs to the target skin, leading an anti-fibrotic effect in scleroderma. This painless transdermal MN platform can be applied to a variety of bioactive agents including peptide and protein drugs requiring prolonged drug activity. |
| 저자 |
임상구, 박규태, 황영준, 성금용, 김재호, 양승윤
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| 소속 |
부산대 |
| 키워드 |
Drug delivery; transdermal peptide delivery; microneedle; scleroderma
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| E-Mail |
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