| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
대학원생 구두발표 |
| 제목 |
Surface Modification of Gd2O3 Nanoparticles with Poly(2-hydroxyethyl methacrylate) for MRI Active Gd-NCT |
| 초록 |
We prepared monodisperse and nano-sized Gd2O3 nanoparticles by using polyol protocol to control the size and particle properties. These Gd2O3 nanoparticles have some characteristics for a potential application like a cancer diagnosis and therapy. The prepared Gd2O3 nanoparticles were coated with hydrophilic poly(2-hydroxyethyl methacrylate) (PHEMA) to enhance the properties (e.g. long circulation in the blood and reduced toxicity) as a MRI active Gd-NCT agent. Effects of hydrophilic PHEMA on the water-solubility in vitro and enhanced residence time in vivo were extensively investigated. (This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2010-0012479)). |
| 저자 |
조희경, 양은지, 정인우
|
| 소속 |
경북대 |
| 키워드 |
Gadolinium; Nanoparticles; Neutron capture therapy; Poly(2-hydroxyethyl methacrylate)
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| E-Mail |
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