| 초록 |
Magnetic resonance imaging (MRI) has been well developed for human health and diagnose of the diseases. Recently, much interest has been focused on polymer-coated nanoparticles (NPs) due to their versatility in biomedical applications. Polymer-coated Gd2O3 NPs can be a promising material to ensure the long-term in vivo stability and low toxicity in human body. The surface-modified Gd2O3 NPs also provide enhanced relaxivity while the polymer prevents the aggregation of the particles. In this work, pH-responsive poly(methacrylic acid)-Gd2O3 NPs for MRI were prepared by using atom transfer radical polymerization of methacrylic acid (MAA) as a protective material via ‘grafting from’ method. Synthesis and physico-chemical properties of PMAA-Gd2O3 NPs will be discussed. (This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2010-0012479)). |
